Interferon gamma is not required for recurrent herpetic stromal keratitis

Recurrent Herpetic Stromal Keratitis CXCL1 but Not IL-6 Is Required for

Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty

This is a case report describing two cases of disciform corneal edema following uncomplicated selective laser trabeculoplasty (SLT) thought to be secondary to herpes simplex virus (HSV) given the presence of a dendrite, decreased corneal sensation, corneal thinning, and response to therapy with oral and topical antivirals. Corneal edema after SLT treatment has been reported before, but the etio...

Effectiveness of levamisole on stromal herpetic keratitis.

Stromal herpetic keratitis has a poor prognosis. To date, corticosteroids appear to be the most efficatious agents against the condition. However, corticosteroids are immuno6uppresive, and may cause recurrences. The recent findings of decreased cellular immunity in the condition offer the possibility of using levamisole as the therapeutic agent. The present investigation was undertaken to evalu...

Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK

Herpes simplex virus 1 (HSV-1) infection of the cornea leads to a potentially blinding disease, termed herpetic stromal keratitis (HSK) that is characterized by lesions of an immunoinflammatory nature. In spite of the fact that HSK typically presents as a recurrent disease due to reactivation of virus which latently infects the trigeminal ganglia, most murine studies of HSK have employed a prim...

Cytokine production in a murine model of recurrent herpetic stromal keratitis.

PURPOSE To determine the pattern of cytokine production in the cornea and its relationship with viral antigens, in our murine model of recurrent ocular herpes simplex virus (HSV)-1 infection. METHODS Six weeks after corneal inoculation with HSV-1, the eyes of latently infected and control mice were UV irradiated and examined for signs of disease and viral reactivation. The eyes of five mice w...